He has won 11 senior caps for Spain.
Spanish newspaper Sport have claimed today that the Premier League sides are interested in the player.
The Gunners return to Premier League action this weekend with a home game against Stoke, while league-leaders Manchester City travel to Crystal Palace.
It has been claimed that Isco has grown frustrated at his position in the Real team, with the 23-year-old no longer a guaranteed starter in the side.
The Independent has launched a new football app! Live scores, in-game stats, breaking news, videos and push notifications are just some of the many features. The 22m-rated Isco joined Real from Malaga for 30m back in 2013. Use the links below to download and get more from Indy Football…